課程資訊
課程名稱
後生遺傳學
Epigenetics 
開課學期
105-1 
授課對象
生物資源暨農學院  生物科技研究所  
授課教師
林劭品 
課號
Biot8001 
課程識別碼
642ED0020 
班次
 
學分
全/半年
半年 
必/選修
必修 
上課時間
星期一6,7,8(13:20~16:20) 
上課地點
生技所415 
備註
本課程以英語授課。與林詩舜合開
總人數上限:20人
外系人數限制:15人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1051Biot8001_Epigene 
課程簡介影片
 
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課程大綱
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課程概述

Introduction–Epigenetic Overview
DNA methylation and genome defense
RNAi and heterochromatin
Evolution of mammalian epigenetic control systems
Epigenetics and development
Epigentics and human disease
X-inactivation
Genomic imprinting in mammals
Genomic imprinting in plants
Epignetics and reprogramming
Epigenetics in assisted reproductive techniques
Applied epigenetics: flowering plants and tissue engineering
 

課程目標
Course description: This graduate course aims to introduce basic epigenetic concepts and research techniques available to address epigenetic questions in mammals as well as other organisms. Students are expected to develop the ability to critically evaluating and interpreting published research articles. They will also learn to extract information from international conferences by listening to experts of each field introducing their research (as in the CD-ROM). 
課程要求
Basic knowledge in Molecular Biology 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
 
參考書目
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
Week 1
9/12  Epigenomics Overview (SP Lin)
20160912 Introduction of Epigneitcs (Part I)
https://www.space.ntu.edu.tw/navigate/s/8DA258617BCD49C7807A5027A2CD1B6BQQY
(Video part II) https://www.space.ntu.edu.tw/navigate/s/07248E2BDB5546A1BEEF04DC12130EF5QQY 
Week 2
9/19  Introduction of functional small RNAs (SS Lin) 
Week 3
9/26  9/26 Functional RNAs and epigenomics (SP Lin)
9/28 9 am~ Mini-symposium on ncRNA (IMB, Academia Sinica)
http://rpas.programs.sinica.edu.tw/ch/events.html 
Week 4
10/03  Leaded Discussion/Students' Showtime (I) (SP Lin)
TE silencing: https://www.space.ntu.edu.tw/navigate/s/8DE1AB331FDF4F8A9158B87526217F4AQQY 
Week 5
10/10  (SS Lin)
Oct 12th, iPSC Strategic Forum, Academia Sinica 
Week 6
10/17  RNA-directed DNA methylation part I (SS Lin) 
Week 7
10/24  RNA-directed DNA methylation part II (SS Lin) 
Week 8
10/31  Epigenomics: From Concepts to Practice (SP Lin) 
Week 9
11/07  Open book mid-term exam 
Week 10
11/14  Long Non-coding RNA part I (SS Lin) 
Week 11
11/21  Epigenomic phenomenons: Genomic Imprinting and X-inactivation <Epigenomics and nuclear architecture in pluripotent stem cells >(SP Lin)  
Week 12
11/28  Epigenomic modulators as drug target <Dynamics of epigenomic regulation during germ cell development >(SP Lin) 
Week 13
12/05  Long non-coding RNA (SS Lin) 
Week 14
12/12  Students' showtime (SP Lin) Part I: Nuclear architecture and ageing  
Week 15
12/19  Students' showtime (SP Lin) PartII: Genomic imprinting and the motherless mice 
Week 16
12/26  (SS Lin: Recap and perspectives in plant epigenomics)
Students' showtime (SP Lin) Part III: Nuclear architecture and ageing-2 
Week 17
1/02  National Holiday; Preparation of paper report to be submitted before 4:10 pm, 9th of January